Breaking the cycle: attacking the malaria parasite in the liver Ute Frevert 2016-01-06 Despite significant progress in the global fight against malaria, this parasitic infection is still responsible for nearly 300 million clinical cases and more than half a million deaths each year, predominantly in African children less than 5 years of age. The infection starts when mosquitoes transmit small numbers of parasites into the skin. From here, the parasites travel with the bloodstream to the liver where they undergo an initial round of replication and maturation to the next developmental stage that infects red blood cells. A vaccine capable of blocking the clinically silent liver phase of the Plasmodium life cycle would prevent the subsequent symptomatic phase of this tropical disease, including its frequently fatal manifestations such as severe anemia, acute lung injury, and cerebral malaria. Parasitologists, immunologists, and vaccinologists have come to appreciate the complexity of the adaptive immune response against the liver stages of this deadly parasite. Lymphocytes play a central role in the elimination of Plasmodium infected hepatocytes, both in humans and animal models, but our understanding of the exact cellular interactions and molecular effector mechanisms that lead to parasite killing within the complex hepatic microenvironment of an immune host is still rudimentary. Nevertheless, recent collaborative efforts have led to promising vaccine approaches based on liver stages that have conferred sterile immunity in humans – the University of Oxford's Ad prime / MVA boost vaccine, the Naval Medical Research Center’s DNA prime / Ad boost vaccine, Sanaria Inc.'s radiation-attenuated whole sporozoite vaccine, and Radboud University Medical Centre’s and Sanaria's derived chemoprophylaxis with sporozoites vaccines. The aim of this Research Topic is to bring together researchers with expertise in malariology, immunology, hepatology, antigen discovery and vaccine development to provide a better understanding of the basic biology of Plasmodium in the liver and the host’s innate and adaptive immune responses. Understanding the conditions required to generate complete protection in a vaccinated individual will bring us closer to our ultimate goal, namely to develop a safe, scalable, and affordable malaria vaccine capable of inducing sustained high-level protective immunity in the large proportion of the world’s population constantly at risk of malaria.
B Cell Receptor Signaling Tomohiro Kurosaki 2015-12-26 This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, while also paving the way for eventually combating these diseases.
Journal of the National Cancer Institute 1998-03
The Journal of Cell Biology 2007 No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Tumor Suppressor Genes Wafik S. El-Deiry 2003 Reviews all the known tumor suppressor genes, explains how they work, and describes how they were discovered and isolated. In many cases, the authors discuss specific genes that are frequently involved in hereditary or sporadic cancers. They also provide a detailed guide to using powerful molecular genetic, cytogenetic, proteomic, and cell biological strategies to discover and isolate novel tumor suppressor genes and their targets. The second volume of this two-volume set, Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medical Applications, shows how to explore the cell biology and biochemical function of such encoded proteins, to study its physiological role in vivo, and to use information on TSGs to develop diagnostic and therapeutic strategies for cancer.
Cancer Research 1995
Optimization Techniques for Solving Complex Problems Enrique Alba 2009-03-23 Real-world problems and modern optimization techniques to solve them Here, a team of international experts brings together core ideas for solving complex problems in optimization across a wide variety of real-world settings, including computer science, engineering, transportation, telecommunications, and bioinformatics. Part One—covers methodologies for complex problem solving including genetic programming, neural networks, genetic algorithms, hybrid evolutionary algorithms, and more. Part Two—delves into applications including DNA sequencing and reconstruction, location of antennae in telecommunication networks, metaheuristics, FPGAs, problems arising in telecommunication networks, image processing, time series prediction, and more. All chapters contain examples that illustrate the applications themselves as well as the actual performance of the algorithms.?Optimization Techniques for Solving Complex Problems is a valuable resource for practitioners and researchers who work with optimization in real-world settings.
Acta Cytologica 1992 Includes abstracts of papers of various symposia.
Flow Cytometry and Cell Sorting Andreas Radbruch 2013-03-14 The analysis and sorting of large numbers of cells with a fluorescence-activated cell sorter (FACS) was first achieved some 30 years ago. Since then, this technology has been rapidly developed and is used today in many laboratories. A Springer Lab Manual Review of the First Edition: "This is a most useful volume which will be a welcome addition for personal use and also for laboratories in a wide range of disciplines. Highly recommended." CYTOBIOS
Peptide Signaling in Plants Qingyu Wu 2022-03-11
Emerging Therapeutics for Immune Tolerance Hyewon Phee 2021-11-30
Epigenetic Therapy with Histone Deacetylase Inhibitors: Implications for Cancer Treatment Christiane Pienna Soares 2021-06-02
The Journal of Immunology 2000
Nanobody Ulrich Rothbauer 2021-03-30 Nanobodies have become outstanding tools for biomedical research, diagnostics and therapy. Recent advances in the identification and functionalization of target-specific nanobodies now make nanobody-based approaches broadly available to many researches in the field. This book provides a compilation of original research articles and comprehensive reviews covering important and up to date aspects of research on nanobodies and their applications for immunoassays, proteomics, protein crystallization and in vitro and in vivo imaging.
The Journal of Rheumatology 1995
The Journal of Neuroscience 1998
Harnessing the Participation of Dendritic Cells in Immunity and Tolerance Silvia Beatriz Boscardin 2020-12-10
Raising Red Flags N.R. Jenzen-Jones 2014-11-18 This report examines the significant range of arms and munitions carried and employed throughout the conflict by armed individuals on all sides. It also examines, somewhat less extensively, the rangeof armoured vehicles and aircraft observed in the conflict. This report examines over 100 distinct weapons systems, over 60 different types of munitions, and over 70 different models of armoured fighting vehicles, as well as miscellaneous associated materiel,in the context of the ongoing conflict in Ukraine. Particular attention is paid to items which mayindicate flows of arms and munitions into and within the affected areas of Ukraine. Beginning with anassessment of the arms and munitions employed during the initial unrest in Kiev, in February 2012, the report documents relevant materiel up until the time of publication
Programmed Cell Death Roya Khosravi-Far 2008-07-29 One of the major goals of researchers in the field of apoptosis is to identify targets for novel therapies in cancer, AIDS, and Alzheimer’s disease. Understanding the molecular mechanisms of the various components of the apoptotic pathways is the first step to reaching this goal. The 2002 Nobel Prize in Physiology or Medicine was awarded to Sydney Brenner (United Kingdom), H. Robert Horvitz (US) and John E. Sulston (UK) "for their discoveries concerning genetic regulation of organ development and programmed cell death." Cell death is a fundamental aspect of embryonic development, normal cellular turnover and maintenance of homeostasis (maintaining a stable, constant environment) on the one hand, and aging and disease on the other. This volume addresses the significant advances with the techniques that are being used to analyze cell death. * This volume provides the necessary, trusted methods to carry out this research on these latest therapeutic techniques. Once researchers understand the molecular mechanisms of the apoptotic pathways, they can begin to develop new therapies. * Presents key methods on studying tumors and how these cancer cells evade cell death. * Eliminates searching through many different sources to avoid pitfalls so the same mistakes are not made over and over.
Novel Design of Complementary Coiled-coil Peptides for the Tumor Suppressor Protein, APC Victoria Allen Sharma 1999
Physics and Technology of Semiconductor Thin Film-Based Active Elements and Devices Halyna Khlyap 2009-04-03 "This well organized reference book covers the newest and most important practically applicable results in thin film-based semiconductor (A2B6-A4B6 and chalcogenide) sensors, heterojunction-based active elements and other devices. This book is written for "
Immunology of Aging Sudhir Gupta 2019-11-05
Single-cell Molecular Characterization for Improving Cancer Immunotherapy Qihui Shi 2022-02-22 Topic Editor Qihui Shi is the scientific co-founder of JunHealth, a company aiming to developing single-cell sequencing technologies for clinical applications, and received research funding from BeiGene.
The Tumor Suppressor Phosphatase PTEN Xinyi Wu 1999
Experimental Biology and Medicine 2009
JNCI, Journal of the National Cancer Institute National Cancer Institute (U.S.) 1987
Ethylene Biology and Beyond: Novel Insights in the Ethylene Pathway and its Interactions Dominique Van Der Straeten 2020-05-21
Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung W. Arber 2012-12-06 The expression of many bacterial genes adapts itself in an almost in stantaneous and reversible way to specific environmental changes. More specifically, the concentration of a number of metabolites, a function of the amounts of enzymes involved in their synthesis or degradation, in turn retroacts on the rate of synthesis of these enzymes. The genetic bases for this regulation were established by JACOB and MONOD (1961). These authors also showed how the known elements of these regulatory mechanisms could be connected into a wide variety of circuits endowed with any desired degree of stability, in order to account for essentially irreversible processes like differentiation (MONOD and JACOB, 1961). The general principles used by JACOB and MONOD in their study of negative regulation were extended to positive regulation by ENGLESBERG et al. (1965). An independent approach permitted the discovery of positive controls in temperate bacteriophages (see below, III). Each control operation is mediated by a pair of complementary genetic elements (hereafter called "control cell"): a control gene which produces a l control (or regulator) protein and a control site which is the target for the regulator protein. Negative control means that the control protein (repressor) prevents gene expression. One deals with positive control when the control protein (activator) is necessary for this expression. It has become apparent that, as initially postulated by JACOB and MONOD, control of gene expression operates, at least to a large extent, at the transcriptional level.
Advances in Immunohistochemistry Ronald A. DeLellis 1988
Journal National Cancer Institute (U.S.) 1978
Schuetzen Rifles; History and Loadings Gerald O. Kelver 1972
Environmental Health Perspectives 1993
Novel Approaches to Target the Immune System in Gastrointestinal Cancers Gianluigi Giannelli 2022-01-31
Journal of the National Cancer Institute 1986 "Summaries of papers" contained in the journal accompany each issue, 19--
Proceedings of the National Academy of Sciences of the United States of America National Academy of Sciences (U.S.) 2007
Genome Research 2006
Vaccines and Immunostimulants for Finfish Hetron Mweemba Munang’andu 2020-12-16
Nature Sir Norman Lockyer 2008
Kalashnikov AK47 Series Martin J Brayley 2013-04-22 Popularly known as the AK47 or just AK, the 7.62mm Avtomat Kalashnikov obrazets 1947g was accepted into service by the Soviet Army in 1947. Despite its widespread use by the Soviet armed forces, the AK only became known in the West during the Hungarian Revolution of 1956, when Soviet troops sent to quell the uprising carried the new weapon. Since then it has become probably the most widely recognized firearm of all time, having seen action in most of the conflicts of the past six decades.The Kalashnikov has been produced in many variants and calibres, and this book concentrates on those in the original 7.62mm form. Illustrated with over 350 colour photographs of AK variants produced around the world, including close-ups of the many fascinating detail differences, this work will be an invaluable addition to the bookshelf of anyone with an interest in modern military firearms. The most widely used firearm of the post-war era - the Kalashnikov rifle has become an icon of revolutionary struggle. Covers the principal design features of the AK variants that used the original 7.62x39mm M1943 cartridge. Will be of great interest to militaria enthusiasts, collectors and military historians of modern military firearms. Superbly illustrated with 350 colour photographs showing the different versions produced around the world. Martin J Brayley has a keen interest in military history and is a professional photogapher, author and dedicated militaria researcher and collector.
Molecular Biology of the Cell 2007

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