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Slavery by Another Name Douglas A. Blackmon 2012-10-04 A Pulitzer Prize-winning history of the mistreatment of black Americans. In this 'precise and eloquent work' - as described in its Pulitzer Prize citation - Douglas A. Blackmon brings to light one of the most shameful chapters in American history - an 'Age of Neoslavery' that thrived in the aftermath of the Civil War through the dawn of World War II. Using a vast record of original documents and personal narratives, Blackmon unearths the lost stories of slaves and their descendants who journeyed into freedom after the Emancipation Proclamation and then back into the shadow of involuntary servitude thereafter. By turns moving, sobering and shocking, this unprecedented account reveals these stories, the companies that profited the most from neoslavery, and the insidious legacy of racism that reverberates today.
Impact of Early Life Nutrition on Immune System Development and Related Health Outcomes in Later Life Laxmi Yeruva 2021-05-28
Colloidal Gold 2012-12-02 Since its introduction in 1971, the development and application of colloidal gold as a marker in electron microscopy has been phenomenal. Colloidal gold has become the method of choice in immunocytochemistry and many areas of cell biology. This universal method is applicable to most microscopical systems including optical microscopy; scanning, transmission, and high voltage electron microscopy; photoelectron, photon, fluorescent darkfield, and epipolarization microscopy. Colloidal gold allows high and low resolution studies, enzyme and nucleic acid labeling, study of dynamic cellular processes, and virus detection. This book is among the first available to cover the principles and methodology of colloidal gold in microscopy. Methods are described step by step, to enable researchers to learn these complex procedures solely by reference to these books Problems and limitations of techniques are discussed Guides users to avoid problems and choose the correct procedures for specific applications Contributors are eminent authorities in their fields
Extra Life Steven Johnson 2021-05-11 “Offers a useful reminder of the role of modern science in fundamentally transforming all of our lives.” —President Barack Obama (on Twitter) “An important book.” —Steven Pinker, The New York Times Book Review The surprising and important story of how humans gained what amounts to an extra life, from the bestselling author of How We Got to Now and Where Good Ideas Come From In 1920, at the end of the last major pandemic, global life expectancy was just over forty years. Today, in many parts of the world, human beings can expect to live more than eighty years. As a species we have doubled our life expectancy in just one century. There are few measures of human progress more astonishing than this increased longevity. Extra Life is Steven Johnson’s attempt to understand where that progress came from, telling the epic story of one of humanity’s greatest achievements. How many of those extra years came from vaccines, or the decrease in famines, or seatbelts? What are the forces that now keep us alive longer? Behind each breakthrough lies an inspiring story of cooperative innovation, of brilliant thinkers bolstered by strong systems of public support and collaborative networks, and of dedicated activists fighting for meaningful reform. But for all its focus on positive change, this book is also a reminder that meaningful gaps in life expectancy still exist, and that new threats loom on the horizon, as the COVID-19 pandemic has made clear. How do we avoid decreases in life expectancy as our public health systems face unprecedented challenges? What current technologies or interventions that could reduce the impact of future crises are we somehow ignoring? A study in how meaningful change happens in society, Extra Life celebrates the enduring power of common goals and public resources, and the heroes of public health and medicine too often ignored in popular accounts of our history. This is the sweeping story of a revolution with immense public and personal consequences: the doubling of the human life span.
What It's Like to Be a Bird David Allen Sibley 2020-04-14 The bird book for birders and nonbirders alike that will excite and inspire by providing a new and deeper understanding of what common, mostly backyard, birds are doing—and why: "Can birds smell?"; "Is this the same cardinal that was at my feeder last year?"; "Do robins 'hear' worms?" "The book's beauty mirrors the beauty of birds it describes so marvelously." —NPR In What It's Like to Be a Bird, David Sibley answers the most frequently asked questions about the birds we see most often. This special, large-format volume is geared as much to nonbirders as it is to the out-and-out obsessed, covering more than two hundred species and including more than 330 new illustrations by the author. While its focus is on familiar backyard birds—blue jays, nuthatches, chickadees—it also examines certain species that can be fairly easily observed, such as the seashore-dwelling Atlantic puffin. David Sibley's exacting artwork and wide-ranging expertise bring observed behaviors vividly to life. (For most species, the primary illustration is reproduced life-sized.) And while the text is aimed at adults—including fascinating new scientific research on the myriad ways birds have adapted to environmental changes—it is nontechnical, making it the perfect occasion for parents and grandparents to share their love of birds with young children, who will delight in the big, full-color illustrations of birds in action. Unlike any other book he has written, What It's Like to Be a Bird is poised to bring a whole new audience to David Sibley's world of birds.
The First Measured Century Theodore Caplow 2001 Companion v. to the PBS television documentary "The first measured century". Includes bibliographical references (p. -296) and index.
The National Parks Dayton Duncan 2009 Presents a narrative history of the American National Park System, examining the events and political battles that led to the establishment of each park while profiling each for its unique attributes, in a volume that also pays tribute to key advocates.
Marine Fisheries Review 1978
Latest Advances on Excitatory Synapse Biology Kimberly M. Huber 2021-11-25
Biological Research Reports from the University of Jyväskylä 1993
Antibody Engineering Volume 1 Roland E. Kontermann 2010-03-10 Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The protocols reflect the latest "hands on" knowledge of key laboratories in this still fast-moving field. Newcomers will benefit from the proven step-by-step protocols, which include helpful practical advice; experienced antibody engineers will appreciate the new ideas and approaches. The book is an invaluable resource for all those engaged in antibody research and development.
The Gene Siddhartha Mukherjee 2016-05-17 The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). "Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself." –Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
Commercial Fisheries Review 1978
Molecular and Cellular Underpinnings of Age-Related Memory Loss Stylianos Kosmidis 2021-10-13
Novel Materials for Carbon Dioxide Mitigation Technology Bryan Morreale 2015-06-01 Materials for Carbon Dioxide Mitigation Technology offers expert insight and experience from recognized authorities in advanced material development in carbon mitigation technology and constitutes a comprehensive guide to the selection and design of a wide range of solvent/sorbent/catalyst used by scientists globally. It appeals to chemical scientists, material scientists and engineers, energy researchers, and environmental scientists from academia, industry, and government in their research directed toward greener, more efficient carbon mitigation processes. Emphasizes material development for carbon mitigation technologies rather than regulations Provides a fundamental understanding of the underpinning science as well as technological approaches to implement carbon capture, utilization and storage technologies Introduces the driving force behind novel materials, their performance and applications for carbon dioxide mitigation Contains figures, tables and an abundance of examples clearly explaining the development, characterization and evaluation of novel carbon mitigation materials Includes hundreds of citations drawing on the most recent published works on the subject Provides a wealth of real-world examples, illustrating how to bridge nano-scale materials to bulk carbon mitigation properties
Checkpoint Controls and Cancer Axel H. Schönthal 2004 Prestigious researchers working at the cutting-edges of their fields comprehensively review the complexities of checkpoint controls and the model systems available to study them. The authors introduce all of the important components of checkpoint controls, describe their intricate interactions, and highlight the relevance of these processes to the cancer problem. Additional chapters illustrate the advantages of using such diverse model systems as intact human skin, knockout mice, Xenopus, and yeast, and show how they can cross-fertilize and accelerate research both across disciplines and beyond the boundaries of a particular species. A second volume, Activation and Regulation Protocols, provides readily reproducible experimental protocols to study the molecular components of checkpoint controls and their regulation.
Clusters Minh Tho Nguyen 2017-01-31 The field of atomic clusters continues to attract great interest amongst physicists and chemists alike. This is in part due to their intrinsic properties and potential industrial applications. The first part of Binary Clusters is devoted to recent developments in experimental techniques, the second part covers a variety of theoretical approaches. Different theoretical methods based on group/graph theories and quantum chemical computational methods as well as various spectroscopy techniques (such as mass, laser, infrared, photoelectron etc.) are applied to the determination of the existence of geometrical and electronic structures, chemical bonding phenomena, and the thermodynamic stabilities of several classes of binary clusters. All chapters within this review volume have been contributed by experts in chemistry, physics, and material sciences based at the University of Leuven, Belgium. This book is aimed at professionals and students working in cluster science.
100 Hikes of a Lifetime Kate Siber 2020 This ultimate hiker's bucket list, from the celebrated Appalachian Trail to Micronesia's off-the-beaten-path Six Waterfalls Hike, treks through 100 energizing experiences for all levels. Filled with beautiful National Geographic photography, wisdom from expert hikers like Andrew Skurka, need-to-know travel information, and practical wildlife-spotting tips, this inspirational guide offers the planet's best experiences for hikers and sightseers. From short day hikes--California's Sierra High Route, Lake Agnes Teahouse in Alberta, Norway's Mt. Skala--to multiday excursions like Mt. Meru in Tanzania and multi-week treks (Egypt's Sinai Trail, Bhutan's Snowman Trek, and the Bibbulum Track in Australia), you'll find a hike that matches your interests and skill level. Crossing all continents and climates (from the jungles of Costa Rica to the ice fields in Alaska's Kenai Fjords National Parks), as well as experiences (a wine route through Switzerland or moose spotting on the Teton Crest Trail in Wyoming,) there is a trail for everyone in these pages. So pack your gear and lace your boots: this comprehensive and innovative guide will lead you to experience the best hikes of your life!
Kalashnikov AK47 Series Martin J Brayley 2013-04-22 Popularly known as the AK47 or just AK, the 7.62mm Avtomat Kalashnikov obrazets 1947g was accepted into service by the Soviet Army in 1947. Despite its widespread use by the Soviet armed forces, the AK only became known in the West during the Hungarian Revolution of 1956, when Soviet troops sent to quell the uprising carried the new weapon. Since then it has become probably the most widely recognized firearm of all time, having seen action in most of the conflicts of the past six decades.The Kalashnikov has been produced in many variants and calibres, and this book concentrates on those in the original 7.62mm form. Illustrated with over 350 colour photographs of AK variants produced around the world, including close-ups of the many fascinating detail differences, this work will be an invaluable addition to the bookshelf of anyone with an interest in modern military firearms. The most widely used firearm of the post-war era - the Kalashnikov rifle has become an icon of revolutionary struggle. Covers the principal design features of the AK variants that used the original 7.62x39mm M1943 cartridge. Will be of great interest to militaria enthusiasts, collectors and military historians of modern military firearms. Superbly illustrated with 350 colour photographs showing the different versions produced around the world. Martin J Brayley has a keen interest in military history and is a professional photogapher, author and dedicated militaria researcher and collector.
Cell Mechanoresponse at Cell-Material Interface Qiang Wei 2022-02-01
Parallel Processing and Applied Mathematics Roman Wyrzykowski 2003-08-01 This book constitutes the thoroughly refereed post-proceedings of the 4th International Conference on Parallel Processing and Applied Mathematics, PPAM 2002, held in Naleczow, Poland, in September 2001. The 101 papers presented were carefully reviewed and improved during two rounds of reviewing and revision. The book offers topical sections on distributed and grid architectures, scheduling and load balancing, performance analysis and prediction, parallel non-numerical algorithms, parallel programming, tools and environments, parallel numerical algorithms, applications, and evolutionary computing and neural networks.
Biotechnological Applications of Phage and Phage-Derived Proteins Sílvio Santos 2019-10-01 Phages have shown a high biotechnological potential with numerous applications. The advent of high-resolution microscopy techniques aligned with omic and molecular tools have revealed innovative phage features and enabled new processes that can be further exploited for biotechnological applications in a wide variety of fields. The high-quality original articles and reviews presented in this Special Issue demonstrate the incredible potential of phages and their derived proteins in a wide range of biotechnological applications for human benefit. Considering the emergence of amazing new available bioengineering tools and the high abundance of phages and the multitude of phage proteins yet to be discovered and studied, we believe that the upcoming years will present us with many more fascinating and new previously unimagined phage-based biotechnological applications.
Methods in Biotechnology Seung-Beom Hong 2016-08-01 As rapid advances in biotechnology occur, there is a need for a pedagogical tool to aid current students and laboratory professionals in biotechnological methods; Methods in Biotechnology is an invaluable resource for those students and professionals. Methods in Biotechnology engages the reader by implementing an active learning approach, provided advanced study questions, as well as pre- and post-lab questions for each lab protocol. These self-directed study sections encourage the reader to not just perform experiments but to engage with the material on a higher level, utilizing critical thinking and troubleshooting skills. This text is broken into three sections based on level – Methods in Biotechnology, Advanced Methods in Biotechnology I, and Advanced Methods in Biotechnology II. Each section contains 14-22 lab exercises, with instructor notes in appendices as well as an answer guide as a part of the book companion site. This text will be an excellent resource for both students and laboratory professionals in the biotechnology field.
Cytokine Molecular Biology Fran Balkwill 2000-11-09 Cytokine Molecular Biology concentrates on molecular biology techniques for the study of cytokines, cytokine receptors, and cytokine driven processes. Updated topics from the previous edition are: the cloning and expressing cytokine genes;; the detection of cytokine mRNA; receptor binding studies; the PC-specific phosphslipase C and sphingomylinases. In addition, new topics covered are the purification, sequencing, and synthesis of cytokines; studying cytokine gene polymorphisms; the use of proteomics in cytokine research; and the Jak/STAT and MAPK signalling pathways. Written by experts in the field, Cytokine Molecular Biology and Cytokine Cellular Biology form a comprehensive and essential guide to cytokine research.
Proteomics in Biology 2017-01-19 Proteomics in Biology Part A, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field, and a focus on proteomics for this updated volume. Continues the legacy of this premier serial with quality chapters that focus on proteomics Contains contributions from leading authorities
Gun Digest Shooter's Guide to AKs Marco Vorobiev 2016-06-15 A practical guide for every AK shooter, serving as a valuable reference manual for the expert, average or novice shooter who wants to learn the fundamentals of operation, maintenance and accessories for the AK rifle.
Novel Natural-based Biomolecules Discovery for Tackling Chronic Diseases Hang Fai (Henry) Kwok 2021-03-29 Natural-based biomolecules continuously play an important role in novel drug discovery for the treatment of chronic diseases. The development of natural peptide/protein-based, toxin-based, and antibody-based drugs can significantly improve the biomedical efficiency of disease-specific therapy. The focus of this Special Issue of Biomolecules will be on the most recent advances related to novel peptides/proteins, antibodies, and toxins as forms of medicinal therapy. Recent advances in the discovery and development of these natural biomolecules for use in targeted therapy and immunotherapy against chronic diseases (e.g., cancer, diabetes, cardiovascular diseases, and rheumatoid arthritis) will be addressed. The discussion on using novel disease-specific proteins/peptides/toxins/antibodies along with currently available FDA-approved drugs as combinatorial treatments will also be encouraged in this context. Finally, an overview of some of the selected promising natural biomolecules that are potentially able to address the forthcoming challenges in this field will be included. Both research (in particular) and review articles proposing novelties or overviews, respectively, are welcome.
Your Inner Fish Neil Shubin 2009 A fascinating chronicle of the evolution of humankind traces the genetic history of the organs of the human body, offering a revealing correlation between the distant past and present-day human anatomy and physiology, behavior, illness, and DNA. Reprint. 75,000 first printing.
Cellular Neurophysiology Editors’ Pick 2021 Enrico Cherubini 2021-07-01
Nanostructured Lead, Cadmium, and Silver Sulfides Stanislav I. Sadovnikov 2017-09-02 This book presents and analyzes the influence of small size particles of lead, cadmium and silver sulfide on the properties of nonstoichiometric semiconductors. Important nonstoichiometry aspects in nanostructures are discussed, such as the distribution of sulfur atoms in nanofilms, a non-periodic distribution of the atomic planes in nanoparticles, interdependent changes in crystal structure of nanocrystalline material. Tuning the stoichiometry allows to obtain superionic conductivity and catalytic activity under visible light. The wavelength of the luminescence of nanoparticles changes with the size of the nanoparticles. Various methods to prepare nanostructured sulfides are described. Special attention is given to the hydrochemical bath deposition as a universal method for the synthesis of sulfides as nanofilms, stable colloidal solutions, quantum dots, isolated nanoparticles with a protective shell and heteronanostructures. The effect of nanoparticle size and nonstoichiometry on the band gap, optical and thermal properties of nanostructured sulfides is also considered. The novel applications of sulfide nanoparticles in nanoelectronics, catalysis, nanobiology and nanomedicine are sketched.
Immunocytochemical Lorette C. Javois 1999 Lorette Javois' timely new 2nd edition revises and updates her widely acclaimed collection of step-by-step immunocytochemical methods, one that is now used in many biological and biomedical research programs. The methods are designed for researchers and clinicians who wish to visualize molecules in plant or animal embryos, tissue sections, cells, or organelles. In addition to cutting-edge protocols for purifying and preparing antibodies, light microscopic analysis, confocal microscopy, FACS, and electron microscopy, this revised edition contains many new methods for applying immunocytochemical techniques in the clinical laboratory and in combination with in situ hybridization.
The Fabric of the Cosmos Brian Greene 2007-12-18 From Brian Greene, one of the world’s leading physicists and author of the Pulitzer Prize finalist The Elegant Universe, comes a grand tour of the universe that makes us look at reality in a completely different way. Space and time form the very fabric of the cosmos. Yet they remain among the most mysterious of concepts. Is space an entity? Why does time have a direction? Could the universe exist without space and time? Can we travel to the past? Greene has set himself a daunting task: to explain non-intuitive, mathematical concepts like String Theory, the Heisenberg Uncertainty Principle, and Inflationary Cosmology with analogies drawn from common experience. From Newton’s unchanging realm in which space and time are absolute, to Einstein’s fluid conception of spacetime, to quantum mechanics’ entangled arena where vastly distant objects can instantaneously coordinate their behavior, Greene takes us all, regardless of our scientific backgrounds, on an irresistible and revelatory journey to the new layers of reality that modern physics has discovered lying just beneath the surface of our everyday world.
Handbook Methods For Oxygen Radical Research Robert A. Greenwald 2018-02-01 This volume is divided into five sections. Section I deals with preparative methodology for isolation and purification of the components of the oxy radical experimental systems use most frequently, including all three forms of SOD and several other important scavengers. Section II provides the experimenter with a choice of a dozen oxy radical generating systems which can be used for testing of scavengers or for evaluation of the effects of oxy radicals on target tissues. The reader will note that in this section, as well as in most of the rest of the volume, the orientation is primarily biochemical, biologic, and medical, rather than pure chemistry or pure physics. Nevertheless, the techniques are widely applicable to a variety of disciplines.
Advanced Cell Culture Technologies to Boost Cell-Based Therapies Dominik Egger 2021-09-15 Dr. Correa is the founder of Lumos Biomed Consulting and holds shares in Cryovida Stem Cell Bank (Mexico). Dr O’Brien holds patents related to regeneration technology and was a co-founder of SurgaColl Technologies. All other Topic Editors declare no competing interests with regard to the Research Topic subject.
Richard Scarry's Cars and Trucks and Things that Go Richard Scarry 1974 On their way to the beach for a picnic, the Pig family encounters almost every kind of transportation vehicle imaginable--and imaginary.
Neurodegeneration: From Genetics to Molecules Victoria Campos-Peña 2016-11-15 Chronic degenerative diseases are one of the major public health problems, particularly those affecting the nervous system. They are characterized by the degeneration of specific cell populations that include several pathologies which contribute significantly to morbidity and mortality in the elderly population. Therefore, in recent years, the study of neuroscience has gained significant importance. Most of these neurodegenerative disorders are the result of a complex interaction between genetic and environmental factors that generate progression and can even determine its severity. The presence of mutations in genes as LRRK2, SNCA, PARK7, PARK2 or PINK1 is associated with Parkinson's disease. Mutations in genes such as APP, PS1 and PS2 are associated with familial Alzheimer's disease; while HTT gene mutations are the cause of Huntington's disease. In most cases, this condition is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. It is known that these mutations can also alter the proteins function; however, it has not yet been possible to fully understand how some genetic changes cause the disease or influence the risk of developing these disorders. Most symptoms seen in these conditions occurs when specific nerve cells are damaged or die generating a loss in brain communication. Also many of these mutations generate aggregation of intracellular or extracellular proteins affecting cell function and eventually causing neuronal death. It is unclear whether the presence of these aggregates play an important role in nerve cell death during the development of neurodegenerative diseases, or if they are simply part of the response of cells to the disease. Other mutations affect the mitochondrial function generating alterations in energy production and promoting the formation of unstable molecules such as free radicals. Under normal conditions, the harmful effects caused by free radicals, are offset within the cell. However, in pathological conditions, the presence of mutations can alter this process by allowing the accumulation of radicals and damaging or killing cells. On the other hand, we also know that these diseases may not have a direct genetic component, thus, the study of sporadic type neurodegenerative diseases is much more complex. Histopathological lesions as well as the cellular and molecular alterations are generally indistinguishable from familial cases. For this reason, it is important to understand the genetic and molecular mechanisms associated with this type of pathologies. In this sense, this issue aims to understand the molecular processes that occur in the brain, and how these are influenced by the environment, genetics and behavior.
Taurine 8 Abdeslem El Idrissi 2013-02-11 Taurine 8 represents the combined efforts of investigators on the roles of the amino acid taurine on human health and disease. The chapters covered in this book are directly derived from presentations of the contributors at the 18th International Taurine Meeting held in Marrakech, Morocco in April 2012. The purpose of this book is to disseminate current findings on taurine's contribution in several organ systems. This book covers the following topics: Taurine in Nutrition and Metabolism, the Protective Role of Taurine, and the Role of Taurine in Reproduction, Development, and Differentiation. Dr. Abdeslem El Idrissi, College of Staten Island and Dr. William L’Amoreaux, College of Staten Island, were co-chairs of the Organizing Committee for the meeting. Data presented at this meeting provided compelling evidence that taurine is not only cytoprotective in cardiomyocytes, but also is a potent GABA agonist, whereby it can facilitate vasodilation of conducting arteries. Taurine conjugates, such as taurine chloramine, may protect cells from oxidative stress via increased HO-1 expression. In adult rodents, taurine has a potent effect on plasma glucose levels, likely through the release of insulin in pancreatic beta cells. As a potential neurotransmitter, taurine is known to work via the GABAergic system, but current research presented at this meeting suggest that taurine may interact with glutamate and serotonin receptors as well. Data are also presented to demonstrate the protective roles of taurine on neurons in neuroblastoma. Perhaps the most important and exciting presentation is the role of taurine and alcohol: the combination may be lethal. Data are also presented at this meeting of the potential role taurine may have as an adjuvant treatment with cisplatin in chemotherapy.
Journal of the National Cancer Institute 2001-11
Neuroanatomy and transgenic technologies Laurent Gautron 2015-04-21 Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions.
Advances in Artificial Intelligence Sabine Bergler 2008-05-20 This book constitutes the refereed proceedings of the 21st Conference of the Canadian Society for Computational Studies of Intelligence, Canadian AI 2008, held in Windsor, Canada, in May 2008. The 30 revised full papers presented together with 5 revised short papers were carefully reviewed and selected from 75 submissions. The papers present original high-quality research in all areas of Artificial Intelligence and apply historical AI techniques to modern problem domains as well as recent techniques to historical problem settings.