Manda was the largest snake in the world, being recently out-sized by his modified clone, Manda II. He easily towered over buildings, trees, and large rock formations. Due to his length, he was even larger than Gamabunta and Katsuyu, easily coiling around Katsuyu and having more length behind him, and he could open his jaws wide enough to swallow Gamabunta whole.
He was coloured purple, and had black rings running down intervals on his body. He had massive fangs, though they were arranged in a way similar to that of a constrictor snake instead of a viper or other venomous snake species, presumably carrying venom in them from the way they were designed, and green eyes. He also had four horn-like protrusions on his head.
Manda was very powerful, and able to stand his own against Gamabunta and Katsuyu, having almost killed them both before being disabled. He was extremely fast, as he was quickly able to dodge and disable Katsuyu. It is also obvious that he was well-known, as Gamakichi was afraid of him just because of his gaze. He was also able to shed his skin in a manner similar to the Body Replacement Technique or Body Shedding, which was seen during the battle with Gamabunta and Katsuyu, and to move underground. His body was sturdy enough to withstand Deidara's ultimate attack, and remain intact, while providing a relatively safe shelter for anyone to hide inside his mouth. Overall, Manda was feared as the "strongest colossal serpent".
After Manda died, Kabuto Yakushi took some cells from his body and included some drugs to clone a stronger version of Manda.